The importance of the let-7 family in the pathophysiology of endometriosis has also been demonstrated in a mouse model, where the introduction of let-7b-5p locally reduced the level of genes known to influence pathogenesis of endometriosis, such as KRAS4A, KRAS4B, ERα, ERβ, Cyp19a, and IL6 [78,136]. The gene discussed is KRAS; the disease is endometriosis.