Therefore, it is clear that let-7b plays an important role in macrophage regulation, with a significant decrease in the expression of proinflammatory genes associated with a simultaneous overexpression of the let-7b miRNA and an increase in cytokine expression as a result of let-7b blocking [89] Additionally, down-regulation of let-7b in the endothelium results in higher levels of TGF-β and its receptors, which enhances the EMT process, which plays a key role in the development of endometriosis [73,78,138]. Here, TGFB1 is linked to endometriosis.