In 1970, Malone [6] and Suzuki and Suzuki [7] showed that the enzyme responsible for the lysosomal hydrolysis of galactosylceramide, called galactocerebrosidase (GALC) or galactosylceramide beta-galactosidase, was deficient in patients with Krabbe disease. Here, GALC is linked to Krabbe disease.