VEGFA and endothelial dysfunction: There is a high prevalence of pre-eclampsia in women with PPCM, and the 2 may share the same pathophysiology.[24] Recent data suggest that antiangiogenic factor sFlt-1 from the placenta antagonizes circulating vascular endothelial growth factor and placental growth factor, leading to hypertension and endothelial dysfunction in pre-eclampsia.