AuNPs were further modified with attachmentof polyethylene glycol (PEG) for stability and Tat, a CPP/nuclearlocalization sequence (NLS), for cellular and nuclear delivery.32−35 Detailed in vitro characterization indicates that 111In-labeled anti-hTR oligonucleotide- and Tat-functionalizedAuNP constructs have a telomerase-dependent cell-killing effect, therebyproviding a new avenue for the treatment of telomerase-positive cancers. The gene discussed is TAT; the disease is cancer.