Now, its association with a constellation of metabolic aberrations including obesity, AGT, IR, non-alcoholic fatty liver disease (NAFLD), metabolic syndrome, sleep apnea, stroke, CVD, neuropsychiatric comorbidities, microalbuminuria, mitogenesis, etc, in addition to cosmetic and reproductive dysfunction, is increasingly being recognized [5-9]. Here, AGT is linked to obesity due to melanocortin 4 receptor deficiency.