RT‐qPCR and Western blot analysis revealed that the levels of MALAT1, HMGB1, TLR4, NF‐κB and IKBa increased and miR‐181a‐5p reduced in pancreas of AP mice, while the trends were reversed in pancreas of AP mice injected with sh‐MALAT1 (Figure 6I). Here, HMGB1 is linked to alkaline phosphatase measurement.