RT‐qPCR and Western blot analysis revealed that the levels of MALAT1, HMGB1, TLR4, NF‐κB and IKBa increased and miR‐181a‐5p reduced in pancreas of AP mice, while the trends were reversed in pancreas of AP mice injected with sh‐MALAT1 (Figure 6I). This evidence concerns the gene NFKBIA and alkaline phosphatase measurement.