Interestingly, pancreatic acinar cells after injury may secrete chemical factors, cytokines and various cell adhesion factors (tumour necrosis factor [TNF], interleukin [IL]‐6, IL‐18, IL‐1β, etc.)to induce the infiltration of immune cells, which contribute to the progression of AP.6 This evidence concerns the gene IL6 and alkaline phosphatase measurement.