ZMPSTE24 and Hutchinson-Gilford progeria syndrome: Nuclear factor κB (NF‐κB) mediates the secretion of high levels of pro‐inflammatory cytokines in the mouse HGPS model caused by the absence of Zmpste24, the integral membrane zinc metalloprotease involved in the proteolytic processing of farnesylated prelamin‐A, the precursor of the nuclear scaffold protein lamin A (Osorio et al, 2012).