LMNA and Hutchinson-Gilford progeria syndrome: However, the role of the NLRP3 inflammasome has not been assessed in genetic models of accelerated aging such as Hutchinson–Gilford progeria syndrome (HGPS), a rare premature aging condition in which a point mutation in the LMNA gene (c.1824C>T; GGC>GCT; p.G608G) (Schreiber & Kennedy, 2013) causes the accumulation of aberrant lamin A precursor of lamin A at the nuclear envelope, resulting in the disruption of the nuclear membrane architecture, abnormal gene transcription, and signal transduction.