Interestingly, in studies investigating metabolic differences occurring under high-fat diets, greater metabolic impairment was observed in Lep wt/- vs wt/wt mice, comprising greater loss of glucose tolerance, hypercholesterinemia, and hepatic steatosis [40] higher insulin levels in male mice [51] and higher serum cholesterol and glucose [49]. The gene discussed is LEP; the disease is fatty liver disease.