An increase in NT-proBNP, adjusted for baseline value, was associated with a higher risk of any serious ventricular arrhythmia, resuscitated cardiac arrest or sudden death [HR per doubling of NT-proBNP, 1.55 (95% CI 1.33–1.81)], whereas a decrease in NT-proBNP was associated with a lower risk [HR per halving of NT-proBNP, 0.65 (95% CI 0.55–0.75)] (Supplementary material online, Appendix Figure S4). The gene discussed is NPPB; the disease is Ventricular arrhythmia.