PDE6D and MORM syndrome: As shown in Fig. 1C and D, EGFP-PDE6D coimmunoprecipitated mChe-fused INPP5E(WT), but not its C-terminal deletion mutant, INPP5E(1-626) (Fig. 1G), which was first found in a family with MORM syndrome and lacks the prenylation site (Jacoby et al., 2009).