IL6 and vitiligo: On the other hand, vitiligo is an autoimmune destruction of melanocytes affecting skin, hair, and mucosa.3,4 The main pathogenesis: 1) Increased proinflammatory cytokine (IL6)8,9; 2) decreased testosterone level and increased serum level of cortisol10; 3) very low vitamin D3 levels have been noted in patients with a variety of vitiligo vulgaris.11,12