However, some hypothesis propose that 1) TNFαi increase the autoreactive T-cells in the peripheral blood, which can penetrate into CNS causing MS-like lesions; 2) TNFαi may cause downregulation of TNF receptors 2 (TNFR2) in the brain, necessary for the proliferation of oligodendrocytes and damage repair; 3) downregulation of IL-10 and upregulation of IL-12 and IFNγ responsible for DD process; and 4) finally, a latent infection may be critical to initiate a DD process.68 The gene discussed is TNFRSF1B; the disease is dentin dysplasia.