Plasma concentrations of the pro-inflammatory cytokines TNF-α and IL-6, of the anti-inflammatory cytokine IL-10, and of myeloperoxidase (MPO), increased progressively with sepsis gravity with no difference between WT and PF4-P2Y12−/−mice (Fig. 6D,E,F, G). Here, P2RY12 is linked to Sepsis.