There are a number of reports on generating sub-replicon expressing or reporter cell lines to assess RNAi-based therapies against the members of Flaviviridae—for instance, Mokhtari et al. generated a MDBK cell line persistently expressing BVDV-5′UTR and BVDV-NS3 via infection with lentiviral vectors (24). This evidence concerns the gene KRAS and infection.