Anemia in HF is usually due to multiple factors, including hypoplastic bone marrow (particularly in older people), inadequate erythropoiesis (vitamin deficiency, low erythropoietin levels, and blunted erythropoietin production) or increased blood loss (hemorrhage and frequent venipuncture, as are common in HF) (22). The gene discussed is EPO; the disease is hydrops fetalis.