It was recently discovered to play a role in the development of various cancers (Lee et al., 2007, 2016; Naudin et al., 2017; Guan et al., 2019), such as ovarian cancer (Guan et al., 2018, 2019), pancreatic cancer (Dai et al., 2019), and leukemia (Naudin et al., 2017), in which PUM1 acted as a tumor promoter. The gene discussed is PUM1; the disease is familial pancreatic carcinoma.