Multiple metabolic genes (AGPS, GART, GLUD1, GMPS, MTHFD1, MTMR2, PAFAH1B2, PIK3CB, PNPT1, and PRIM2) related to aggressiveness and poor outcomes in cancer showed higher expression levels in the C1 group than in the C2 group. The gene discussed is PAFAH1B2; the disease is cancer.