Multiple metabolic genes (AGPS, GART, GLUD1, GMPS, MTHFD1, MTMR2, PAFAH1B2, PIK3CB, PNPT1, and PRIM2) related to aggressiveness and poor outcomes in cancer showed higher expression levels in the C1 group than in the C2 group. This evidence concerns the gene MTHFD1 and cancer.