MAPT and early-onset autosomal dominant Alzheimer disease: Deferoxamine treatment immediately after brain reperfusion decreases infarct volume (Hanson et al., 2009), and suppressing tau, a protein of Alzheimer’s disease, protects against cerebral ischemia-reperfusion injury in young mice via ferroptosis inhibition, with ferroptosis inhibitors, such as liproxstatin-1 and Fer-1, reviving the protection provided by tau knockout in older mice (Tuo et al., 2017).