Although the functional significance of IL13RA2 expression is not fully understood, it is considered an inhibitory or decoy receptor in GBM (Rahaman et al., 2002) that contributes to tumor growth (Hsi et al., 2011) and several studies have found that its overexpression is associated with higher glioma grades and poor patient prognosis (Brown et al., 2013; Han and Puri, 2018). Here, IL13RA2 is linked to central nervous system cancer.