IL1B and dengue disease: In dengue infection, IL-1β increased in severe dengue (Suharti et al., 2002; Bozza et al., 2008; Wang et al., 2019; Pan et al., 2019a; Pan et al., 2019b), which is associated with thrombocytopenia (Bozza et al., 2008), tissue injury and vascular leakage (Pan et al., 2019a; Pan et al., 2019b), and fibrinolysis (Suharti et al., 2002).