In case of DENV-2, significant upregulation in IL-12 (p<0.05) and IFNγ (p<0.05, Figure 6H) was observed in primary infection than secondary; while GM-CSF (p<0.0001, Figure 6H) and IP-10 (p<0.01, Figure 6I) were upregulated in secondary than primary infection. This evidence concerns the gene CSF2 and infection.