In DENV-2 genotype, T164S mutation in NS1 protein ascertains the fact that mutation in dengue protein can enhance clinical severity (Rodriguez-Roche et al., 2005), as well as increased Th1 response—IL-6, IFNγ, and TNFα—in in vivo and in vitro experimental model (Sierra et al., 2012; Chan et al., 2019). This evidence concerns the gene IL6 and dengue disease.