CXCL8 and infection: In DENV-4, IL-2 (p<0.05), IL-8 (p<0.01), IL-12 (p<0.01), and IFNγ (p<0.001) were significantly upregulated in primary than secondary infection, while GM-CSF (p<0.0001) and IP-10 (p<0.001) were significantly upregulated in secondary infection.