However, mutations in PBRM1 have showed a negative impact on patient survival in ccRCC and BRCA (30–32).By comparing the effects of PBRM1 on OS and DFS in different tumors, we found that PBRM1 has significantly greater effects on ccRCC than in other tumors (Figure 3A). This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.