As shown in Figure 1A, in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC, ccRCC), kidney renal papillary cell carcinoma (KIRP) tumors, there was a significant decrease in the expression level of PBRM1 RNA in cancers compared with normal tissues. The gene discussed is PBRM1; the disease is colon adenocarcinoma.