Consistently, the results of our study revealed that FOXM1 could upregulate the expression of Linc-ROR in HNSCC cells, while the knockdown of Linc-ROR was shown to normalize the stimulatory effect associated with FOXM1 on tumor growth in the xenograft model of HNSCC cells. The gene discussed is LINC-ROR; the disease is head and neck squamous cell carcinoma.