This is supported by a study carried out in Queensland, Australia, reporting that individuals with ≥ 20 nevi (≥ 5 mm diameter) and MC1R R/R genotype have a 25-fold increased melanoma risk, compared to people with 0 to 4 nevi and the MC1R WT/WT genotype; while individuals with ≥ 20 nevi and the MC1R R/R genotype have an absolute melanoma risk to age 75 of 23,3% for men and 19, 3% for women [10]. The gene discussed is MC1R; the disease is melanoma.