TP53 and cancer: As a result, 14-3-3 modulates the subcellular localisation, protein folding, enzymatic activity or biomolecular interactions of the partner protein.20 We chose to focus on three important 14-3-3 PPIs between 14-3-3σ and LRRK2,21 ERα22 and p53 23,24 which are implicated with Parkinson's disease and cancer, and which are known to be differentially stabilised by fusicoccin A (FC-A).