When we reviewed the ER stress response, a lot of research articles on the treatment of drugs in T2DM db/db mice have been found, and most of them focus on the mechanism of ER stress response in diabetic nephropathy (DN) [38, 39], but researches about endoplasmic reticulum in glucose metabolism and insulin sensitivity have been largely ignored [23, 40]. Here, INS is linked to diabetic kidney disease.