Yu et al. (2020) have found that hsa-mir-125b suppresses cell proliferation and metastasis by targeting HAX-1 in ESCC, which proves that hsa-mir-125b is related to esophageal neoplasms. Moreover, the predicted association score between hsa-mir-200b and esophageal neoplasms is ranked second. Researchers have confirmed that hsa-mir-200b is downregulated in ESCC in the comparison of the respective adjacent benign tissues (Zhang et al., 2014). Here, HAX1 is linked to neoplasm of esophagus.