In the cardiovascular system, circFndc3b can reduce cardiomyocyte apoptosis and fibrosis and enhance angiogenesis by promoting VEGF expression and signaling via its interaction with the RNA-binding protein fused in sarcoma (FUS) after myocardial infarction (MI) (Garikipati et al., 2019). The gene discussed is FUS; the disease is myocardial infarction.