FLCN and renal cell carcinoma: While the tumor suppressor activity of FLCN was confirmed by nude mouse xenograft assays of two human RCC cell lines with either diminished or re-expressed FLCN (Hudon et al., 2010), a recent report showed a 14-year-old patient with early-onset bulky RCC harboring a deletion in FLCN exon 5 (Schneider et al., 2018).