Reid and Nacheva (2004) identified a patient with an aggressive form of CML harboring a submicroscopic insertion of sequences from chromosome 9q34.1 into chromosome 7q35. The PRDM12 and FUBP3 genes were included in this insertion. It was therefore hypothesized that loss of PRDM12 expression could be responsible for the aggressive state of the disease in this patient. Here, PRDM12 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.