However, the severity of destructive β cell autoimmunity in DT-treated adult NOD.DEREG females appears rather unexpected, in particular in light of previous studies on Foxp3+ Treg cell targeting using anti-CD25 mAb and the moderate spontaneous diabetes incidence that we observed in the present study in DT-untreated NOD.DEREG mice (Supplementary Figure S1A). Here, FOXP3 is linked to diabetes mellitus.