SNAIL, a transcription factor expressed during epithelial-mesenchymal transition, activates the production of tumor-derived exosomes containing miR-21 that will be phagocyted by monocytes leading to M2 macrophages, secretion of IL6, IL8, CCL2, and CCL5 impacting in higher angiogenesis, and tumor growth (74) (Figure 4). Here, CCL2 is linked to neoplasm.