Pro-inflammatory cytokines, such as interleukin (IL)-12, IL-6, IL-1β, and tumor necrosis factor (TNF) might play a fundamental role in the onset and progression of NAFLD promoting insulin resistance, oxidative stress, hepatic inflammation, cell necrosis, apoptosis, and liver fibrosis (12, 13). The gene discussed is TNF; the disease is Hepatic fibrosis.