In this context, an overproduction of proinflammatory cytokines, such as TNF and IL-6 connected to a defect in the function or production of anti-inflammatory cytokine IL-10 could increase nitric oxide and lipid peroxidation, enhancing steatosis severity (43) as observed in histological founds of NASH group. This evidence concerns the gene IL10 and metabolic dysfunction-associated steatohepatitis.