ALPS-like phenotype was seen in a significant percentage of patients suffering, among others, from mutations in STK4, STAT3 (GOF), LRBA or CARD11 (GOF) (66.7%, 61.1%, 55.9% and 53.3%, respectively, corresponding to 223 out of 390 patients), while the combination of autoimmunity and lymphoproliferation is quite rare in others. The gene discussed is STAT3; the disease is Autoimmunity.