Several ALPS-like patients with elevated DNT suffering from CTLA4 haploinsufficiency, LRBA, TPP2, ADA2 and IL2RB deficiencies, RALD syndrome or CARD11 GOF were treated and responded to this drug (31, 44, 55, 61, 71, 83, 96–98) (Table 1). This evidence concerns the gene CARD11 and autoimmune lymphoproliferative syndrome.