To date, thirteen genes have been related with ALPS-like syndrome in the literature: phenocopies of PID (NRAS and KRAS), susceptibility to EBV (MAGT1, PRKCD), regulatory T-cells defects (CTLA4, LRBA, STAT3 GOF), combined immunodeficiencies (ITK, STK4), defects in intrinsic and innate immunity and predisposition to infection (STAT1 GOF, IL12RB1) and autoimmunity/autoinflammation (ADA2, TET2) (18–29). Here, STAT3 is linked to Autoimmunity.