PIK3R1 and hereditary disease: In this study, twenty-four genetic disorders with ALPS-like characteristics have been identified in the literature: PRKCD, MAGT1, XIAP, SH2D1A, RASGRP1, TNFRSF9, ITK, STK4, CTLA4, LRBA, CD25, CD122, DEF6, TET2, TPP2, IL12RB1, ADA2 and TNFAIP3 deficiencies, PIK3CD, STAT3, STAT1 and CARD11 gain of function, PIK3R1 loss of function and RALD (caused by somatic gain of function mutations in NRAS and KRAS genes).