Susceptibility to predominantly viral infections was observed in TET2, TPP2 and TNFAIP3 patients (27, 61, 62) while chronic mucocutaneous candidiasis (CMC) and mendelian susceptibility to mycobacterial disease (MSMD) were characteristic of STAT1 GOF and IL12RB1 patients, respectively (40, 63). Here, IL12RB1 is linked to viral infectious disease.