Although ALPS parameters are not provided in most of reviewed literature, increased DNT values have been reported in some ALPS-like patients with a defect in PIK3CD GOF (74), ITK (19), STK4 (22), STAT3 GOF (24, 43, 46, 75, 76), CTLA4 (55, 60), LRBA (16, 20, 47, 67, 77–81), IL2RA (82), TET2 (27), IL12RB1 (26, 63), ADA2 (28, 58, 83, 84), TNFAIP3 (62, 85), NRAS/KRAS (86–89) and CARD11 GOF (59, 71, 90, 91) genes, while DNT values within the normal range were observed in PRKCD (92, 93), MAGT1 (23, 94), RASGRP1 (69) and TPP2 (61) ALPS-like patients (Table 1 and Figure 3A). Here, PIK3CD is linked to autoimmune lymphoproliferative syndrome.