Skin involvement was remarkable in TNFAIP3 and ADA2 deficiencies, but it was one of the most common manifestations among ALPS-like disorders (Figure 2), mainly in form of non-infectious skin rashes, psoriatic-like lesions, skin abscess, severe eczema and skin warts (usually due to papilloma virus infection). This evidence concerns the gene ADA2 and Skin rash.