In this study, twenty-four genetic disorders with ALPS-like characteristics have been identified in the literature: PRKCD, MAGT1, XIAP, SH2D1A, RASGRP1, TNFRSF9, ITK, STK4, CTLA4, LRBA, CD25, CD122, DEF6, TET2, TPP2, IL12RB1, ADA2 and TNFAIP3 deficiencies, PIK3CD, STAT3, STAT1 and CARD11 gain of function, PIK3R1 loss of function and RALD (caused by somatic gain of function mutations in NRAS and KRAS genes). Here, DEF6 is linked to hereditary disease.