Recently, it was shown that peroxisome proliferator-activated receptor α (PPARα) activation is required for the activation of TFEB, which is essential for antimicrobial responses and intraphagosomal acidification, i.e., phagosomal colocalization with the lysosomal marker LAMP1, during Mabs-S infection (Kim Y. S. et al., 2020). This evidence concerns the gene PPARA and infection.