MAPK3 and brain ischemia: Chen et al., 2020 research shows that THSWD can promote angiogenesis after cerebral ischemia in rats by regulating platelet particles, and then treating cerebral ischemia. Other studies have shown that THSWD may regulate the survival of neurons by upregulating the expression of brain-derived neurotrophic factor (BDNF), activating the BDNF-TrkB-ERK1/2 signaling pathway, there by promoting the recovery of cerebral ischemic injury (Wu, 2018).