4-MTBITC treatment attenuated DMBA induced alteration in leptin (29% at p < 0.05) and adiponectin (52% at p < 0.01) levels compared to group B. It was observed that the levels of insulin were significantly increased (94% at p < 0.01) in cancer-bearing rats as compared to control (Figure 5C). This evidence concerns the gene LEP and cancer.