In addition, CD40 IR was associated with an increase in the concentration of CD40L in the hippocampus (Control: mean 26.10 ± 7.6 S.E.M., n = 4 vs. Seizure: mean 57.77 ± 9.7 S.E.M., n = 8; p = 0.02; t = 2.5) and cortex (Control: mean: 24.90 ± 3.13 S.E.M., n = 4 vs. Seizure: mean: 52.93 ± 4.96 S.E.M., n: 9; p = 0.0006, t = 2.20) respectively (Fig. 2E). This evidence concerns the gene CD40 and Seizure.