On the other hand, 21 of our most relevant WH proteins (ACTG1, ANXA1, CDKN1A, CRK, ERBB2, F2, FLNA, FZD6, GNA13, GNAS, GP5, HMGB1, KNG1, MTOR, NF1, NFE2L2, NOTCH2, P2RY12, SDC4, VEGFA, and YAP1) had shortest paths of positive regulation to the cancer hallmark phenotypes whose path scores are detailed in Fig. 7 and Supplementary Table 17. The gene discussed is HMGB1; the disease is cancer.