MTOR had the shortest path to sustaining proliferative signaling (0.47), TLR4 to differentiation (0.78), HIF1A to deregulating cellular energetics (0.80), PAK1 to resisting cell death (2.27), NFE2L2 to metastasis (0.86), CCL2 to tumor-promoting inflammation (0.73) , and FGF2 to angiogenesis (0.86). The gene discussed is PAK1; the disease is neoplasm.