Similar to costimulatory and other surface expressed molecules, mRNA expression of TLR4 (10.7-fold) and TLR21 (15-fold) was upregulated in S. Typhimurium-treated chMoDCs at 6 h post-infection (P < 0.001) but reduced almost to a basal level at 24 h post-infection (Fig. 6a). The gene discussed is TLR4; the disease is infection.