TP53 and neoplasm: TCGA samples are from 33 different tumor types, keeping in mind differences in C-terminal and NM_001126112.2 alternative isoforms expression across different tissue types, we performed comparisons between TP53 WT tumors (no TP53 mutations, log2(CN-ratio) > − 0.9 and TP53 mRNA RNA-Seq V2 RSEM normalized > 300) and tumors with TP53 missense mutations in each tumor type with at least 5 samples in each group.