We identified 35 genes that were more frequently altered in HS/CB tumors versus corresponding TCGA cohorts; of which, 8 genes (PREX2, BIRC6, CNTNAP2, PTPRB, GRM3, ANKRD11, BRCA2, and TET3) are listed on the OncoKB Cancer Genes catalogue (Supplementary Data 2). The gene discussed is ANKRD11; the disease is cancer.