IFNG and neoplasm: To examine whether pre-existing transcriptional signatures of immunological activity and immune cell subpopulation composition in the tumor are associated with pembrolizumab sensitivity and clinical response, we investigated previously published gene-expression signatures for total immune infiltration (IM; inferred total immune infiltration score)18, interferon-gamma signaling (IFNG)19, cytolytic activity (CYT)5, and abundances of 22 immune cell populations inferred by CIBERSORT deconvolution analysis in 65 baseline tumors (CB rate = 30%).