TIGIT and neoplasm: Within the 45 DRGs with higher level of induction in HS/CB, we identified CD8 marker genes (CD8A and CD8B), IFN gamma response genes (PYHIN1, CXCR6, CXCL13, CXCL11, WAS, GBP5) inhibitory checkpoint molecules (PDCD1, TIGIT, CTLA4)1 (Fig. 5A, C), and cytolytic molecules with anti-tumor activity (GZMA, GZMB)5.