The three COVID-19 vaccines authorized for emergency use by the U.S. Food and Drug Administration (BNT162b2 [Pfizer–BioNTech], mRNA-1273 [Moderna], and Ad26.COV2.S [Janssen]) elicit immunity using a spike protein antigen derived from early isolates such as USA_WA1/2020 (WA1)17. This evidence concerns the gene CHMP5 and COVID-19.