To interrogate its clinical translation value using TCGA datasets, we created a surrogate human gene signature composed by Il12b, Ifng, Cd8b, Gzma, and Cd38. Probing this gene signature across a range of tumor types revealed that patients harboring high gene expression levels of this signature had a significantly higher overall survival relative to those with low gene expression (Fig. 8c). Here, CD8B is linked to neoplasm.