This shift in the TAM balance favoring tumor resolution elicited by combination therapy was further supported by elevated expression of the “eat-me signal” calreticulin over the “don’t-eat me signal” CD47 on CD45neg non-immune/tumor cells in the TME upon combination therapy (Supplementary Fig. 6), collectively suggesting a pattern conducive to macrophage-mediated tumor clearance49. This evidence concerns the gene CALR and neoplasm.