In conclusion, using comprehensive TME single-cell transcriptome, proteome, and immune cell analysis, we demonstrated that combination therapy elicits significant and sustained antitumor efficacy and complete responses by shifting the tumor immunome to a functionally inflamed landscape, where the concerted actions of highly active CD8+ T cells, neutrophils, and M1-like antitumor macrophages leads to complete tumor eradication. Here, CD8A is linked to neoplasm.