Collectively, this resulted in a crescendo in M1 polarization, reprogramming the TME to an inflamed hub where the elevation of monocyte (CCL3, CCL4, CCL5) and CD8 T cell‒attracting chemokines (CXCL9, CXCL10, CCL5) by activated neutrophils and/or macrophages further promoted tumor engraftment of highly functional IFNγ- and TNFα-producing CD8+ TILs through a sustained circular loop leading to tumor eradication. The gene discussed is TNF; the disease is neoplasm.