CD4 and HIV infectious disease: Our results from in vitro HIV infection experiments support transcriptomic and flow cytometric profiling results from HIV+ patients undergoing suppressive antiviral therapy, whose oral mucosa also revealed TLR signaling pathway upregulation and an inflammasome gene signature that paralleled excessive CD4+ T cell activation and enrichment of PD-1highIFN-γ+AREGhighFOXP3+ cells (Figs. 1 and 8).