Besides inflammatory cytokines, during the cytokine storm, some proinflammatory cytokines (IL- β, -6, -12, -18, and -33 and TNF-α) are always increased in SARS-CoV infection.240,241 Moreover, the incidence of cytokine storm is regulated by the demethylation of IFN-regulated and cytokine genes.242 Hence, decreasing the plasma level of inflammatory or/and proinflammatory cytokines epigenetically are potential targets to cure COVID-19. The gene discussed is TNF; the disease is COVID-19.