D614G mutation of S protein was found with increased transmissibility, which played a predominant role early in the COVID-19 pandemic.112,113 However, among vaccinated individuals and patients with COVID-19, this mutation showed a mild effect on neutralizing their sera.114 Recently, several variants of SARS-CoV-2 with increased transmissibility have emerged worldwide, compromising virus control and raising concerns that the unknown and constant mutations might weaken current efforts on combating the pandemic. Here, PROS1 is linked to COVID-19.