Furthermore, histopathological and immunohistochemical tests showed that TMPRSS2 expression affected the primary site of infection and the transmission of the virus in the airway with different immunopathologies.219 Considering the forceful preclinical support of camostat mesylate for SARS-CoV2 infection, several clinical trials assessing it alone or in combination with HCQ have been initiated in Europe and the United States. The gene discussed is TMPRSS2; the disease is infection.