The variant B.1.1.7 of SARS-CoV-2 (UK variant), also named as 501Y.V1 or variant of concern 202012/01, first emerged in England, has caused a surge in COVID-19 cases.115 This variant has been reported to be spread to >50 countries and seems to become virulent in the future.116–118 It has eight S protein mutations except for D614G.119 SARS-CoV-2 B.1.351 (501Y.V2) and P.1 (501Y.V3), also termed as South Africa variant and Brazil variant, respectively, were claimed to have more strong infectious ability. Here, PROS1 is linked to COVID-19.