In ccRCC, hypomethylation of both CpG sites within the promoter was inversely correlated with CTLA4 mRNA expression with significant Spearman’s correlation coefficients: CpG1 ρ=−0.54; CpG2 ρ=−0.51 (both p<0.001, figure 1E, F). The gene discussed is CTLA4; the disease is nonpapillary renal cell carcinoma.