Memory CD8+ T cell generation is therefore an important goal of current efforts for successful cancer immunotherapies.43 ZSTK474 decreased the expression of phosphorylated Akt and S6 not only in Tregs but also in CD8+ T cells, although CD8+ T cell proliferation was only marginally suppressed by ZSTK474 both in humans and in murine models. The gene discussed is AKT1; the disease is cancer.