CD8A and neoplasm: There are at least two types of tumor antigens: (1) tumor-specific antigens (TSAs), which are either oncogenic viral proteins or abnormal proteins stemming from somatic mutations (neoantigens), and (2) tumor-associated antigens (TAAs), which are highly or aberrantly expressed normal proteins.27 As surrogate TSAs, we employed cytomegalovirus (CMV) and influenza virus (Influenza), and assessed antigen-specific CD8+ T cell responses against CMV and Influenza using CMV/HLA-A*0201 and Influenza/HLA-A*0201 tetramers.