We predicted that BSCB damage would be most severe in the anterior part of the cervical and lumbar cord, given that lower motor neurons in these regions innervate the limbs, which are most commonly affected in ALS [1, 5], and lower motor neuron loss with phosphorylated TDP-43 proteinopathy is greatest in the cervical and lumbar cord [our findings and 5]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.