This method came to attention after two of its products, axicabtagene ciloleucel or Axi-cel (yescarta, Kite) and Tisagenlecleucel (kymriah, Novartis), were approved by the FDA for the treatment of diffuse large B-cell lymphoma (DLBCL) and CD19+ B-ALL [19]. The gene discussed is CD19; the disease is acute lymphoblastic leukemia.