It could promote the production of a variety of pro-inflammatory or hematopoietic cytokines, chemokines, matrix metalloproteinases plus effecting the expansion of neutrophil through granulocyte colony-stimulating factor (G-CSF) and chemotaxis (CXC), thus aggravating the immunologic derangement characteristic of ITP [16]. Here, CSF3 is linked to autoimmune thrombocytopenic purpura.