VIRMA and cancer: VIRMA (or vir-like m6A methyltransferase associated) is a critical part of the methyltransferase complex (which includes METTL3, the catalytic component, as well as other players such as WTAP and METTL14 that work together to stabilize and allow the functionality of the complex) and was shown to contribute to cancer progression in multiple malignancies by regulating cell cycle progression, migration, invasion, resistance to apoptosis and tumor growth, in both m6A dependent and independent manners [22].